LS2Protein_structure

LS2Protein_structure - Protein structure 1. Amino acids 2....

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Protein structure 1. Amino acids 2. Protein structure peptide bond, primary, secondary, tertiary, quaternary structure domain 3. Protein folding & modification
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Protein Proteins are polypeptides made up of amino acids There are 20 different amino acids , each with different chemical properties The 3D shape a protein adopts is determined by its sequence of amino acids The large number of 3D shapes that proteins can assume allows them to perform a wide range of functions
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Basic Structure of Amino Acids
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Glycine - smallest side group Cysteine - forms disulfide bonds (covalent bond) Proline - the only cyclic amino acid. Often involved in bends in protein chains.
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Peptide bonds The covalent bond between two adjacent amino acids in a peptide is called peptide bond. 6N HCl breaks peptide bonds and hydrolyzes polypeptides
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The peptide bond is formed by joining the amino end of one amino acid to the carboxyl end of another amino acid. ..
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protein sequence comparison G LS DG E WQL V LN V W GKV E A DIPGH G QE V L I R L F KGH P ETLEKF G LS DG E WQL V LN V W GKV E A DLAGH G QD V L I R L F KGH P ETLEKF E LS EA E RKA V QA M W ARL Y A NCEDV G VA I L V R F F VNF P S----- D.M. H.M. H.H D.M. Dolphin myoglobin, H.M. human myoglobin, H.H. human hemoglobin Protein homology : means either identical amino acid or similar amino acid. This is because change of an amino acid in a protein to a different amino acid with similar chemical property usually cause no harm to the protein with respect to its function. Similar amino acids: - acidic: E, D - basic: K, R, (H), - polar uncharged: S, T, N, Q, C, (H), (Y) - hydrophobic: L, I, A, V, G, M, F, P, W, (Y) - some are less sure than others (e.g. Y, H).
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Proteins are polypeptide polymers made up of amino acids 20 amino acids are used to make up
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This note was uploaded on 03/14/2012 for the course LS 3 taught by Professor Lin during the Fall '06 term at UCLA.

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LS2Protein_structure - Protein structure 1. Amino acids 2....

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