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Exam3_VeryGenericStudyGuide - Translocations Polyploidy in...

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Study Guide, Exam 3, taken from brief learning outcome outlines There is a lot of detail in what we have covered so far. You would do well to study under a hierarchy: 1. Know the terminology, 2. Understand the process and 3. Understand the big picture and relevance of each section. Genome structure and packaging Understand what the C-value paradox is and what drives it Chromosome structure: supercoiling, nucleosomes, the steps of DNA condensation Telomeres and telomerase Chromosome abnormalities in human pregnancies Down’s syndrome Segregation of the trisomic chromosome Changes in chromosome structure: process and consequences Deletions Duplications Inversions
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Unformatted text preview: Translocations Polyploidy in plant evolution Genomics • What is genomics? • What’s in a genome? • Why is genomic information relevant? • What molecular tools have made genomics possible? o Cloning, or recombinant DNA Plasmids: types, length of fragment accepted, what makes a good plasmid? o Basic principles of restriction enzymes: cleavages will produce what type of overhangs and/or sequence? o Production of cDNA, and RT-PCR o Plasmid structure and phenotypic screening for positive clones • Functional genomics, techniques Human Genetics • Human genetics draws on what subfields of genetics? • Human clinical genetics—key points?...
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