{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Homework2

# Homework2 - Name M612 Last'rst Homework H a hormone binds...

This preview shows pages 1–2. Sign up to view the full content.

This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Name M612? Last, 'rst Homework H, a hormone, binds to receptor R with a dissociation constant, KH, of 4 x 10‘7 M. (The RH complex then triggers some biochemical process, such as cAMP formation but this is not relevant to the present problem.) D, a drug, binds to the receptor with a dissociation constant, KD, of 6 x 10-6 M. The D site is distinct from the H site so that both D and H can occupy the receptor simultaneously. Thus, D can also bind to the RH complex; H can also bind to the RD complex. (The RDH complex, however, is unable to trigger cAMP formation.) The dissociation constant for the RH + D reaction is 5 x 10‘7 M. 1. Draw all the equilibrium reactions of the "linked" functions described above. 0 D ms 11‘ M» RD + RDH xx“ 2. Calculate the constant for the dissociation of H from RDH. MW: ( lock) . <4x(o*?‘)<5x(cr7> 2 (Q W) “M ~13 42,3101 ~» 04 KH ‘ é K1047 (continued) 7/“, K M‘- ffll: 04K” 3. 4 _ [NEH] _ EHJLDJ 1. LPJLDJL/i] LP‘ " ‘ MD ‘ “K01?” y XD/ E01?) 2 1‘- J , '. I} T i x I + % 4 ‘7};— + Calculate the fractions (i.e., proportions, percentages) of each R species (R, RH, RD, etc.) when: 3- [H]=4x10'7Mand[D]=o. ‘1 v‘ (:03 '2 0/ Wrctbre [RD] 0L [RD/7’ +11%}va 4a: m 4x116 su‘ ' i (51'qu {6' 117" (a! 1’0"”! V, 1‘, \$5] (73¢ [L Dl=6x10-6M. , I ___——-l-—__—- - / : 2 Mlvﬂﬁ‘SWY ' IWS . (1, Increasing the concentration of D at any ﬁxed free [H] will N‘Cfggﬁcc the binding of H. (write “increase” or “decrease”) 4 KH/ Wash/1; 1)}an may/“C ﬁjflw Ciidc‘ D Is [Marv]. ...
View Full Document

{[ snackBarMessage ]}

### What students are saying

• As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

Kiran Temple University Fox School of Business ‘17, Course Hero Intern

• I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

Dana University of Pennsylvania ‘17, Course Hero Intern

• The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

Jill Tulane University ‘16, Course Hero Intern