121 MT2 WhiteKey - Name White Key Last MCB121 Page 1 of 9...

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Name White Key MCB121, Page 1 of 9 Last, First Gasser, Burgess ©2012 Charles S. Gasser, my not be reproduced without permission of author. MCB121 Second Midterm, Feb 28, 2012 Instructions: There are nine pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. Amino acid Abbreviations Amino acid Abbreviations Alanine Ala A Leucine Leu L Arginine Arg R Lysine Lys K Asparagine Asn N Methionine Met M Aspartic acid Asp D Phenylalanine Phe F Cysteine Cys C Proline Pro P Glutamine Gln Q Serine Ser S Glutamic Acid Glu E Threonine Thr T Glycine Gly G Tryptophan Trp W Histidine His H Tyrosine Tyr Y Isoleucine Ile I Valine Val V
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Name White Key MCB121, Page 2 of 9 Last, First Gasser, Burgess ©2012 Charles S. Gasser, my not be reproduced without permission of author. Question Value Score 1 15 2 15 3 15 4 12 5 15 6 9 7 22 8 16 9 19 10 12 Total 150 1. (15) Match each of the following factors/elements with a role it plays in transcription (one letter per blank, do not use letters more than one time). __ G __Mediator complex A) Requires UTP to perform its normal function. __ D __CTD kinase B) Can make direct contact with the DNA- binding domain of a particular regulatory transcription factor. __ B __Enhancer C) A site in DNA for binding of a general transcription factor __ F __Insulator D) Can add phosphate groups to another protein to enable transcription __ A __RNA polymerase II E) Can remove phosphate groups from a protein to allow multiple rounds of transcription F) Can interrupt the propagation of histone deacetylation across a region of chromatin. G) Commonly makes direct contact with activation domains of some regulatory transcription factors.
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Name White Key MCB121, Page 3 of 9 Last, First Gasser, Burgess ©2012 Charles S. Gasser, my not be reproduced without permission of author. 2. (15) Mark the single most correct answer to each of the following. a) (5) TFIIH is important for which of the following? Enables RNA Pol II to join the PIC. Has a helicase activity that separates snRNP U4 and snRNP U6 during splicing reactions. Facilitates chromatin remodeling following binding of glucocorticoid receptors to DNA. Makes enhancers bi-directional. X Catalyzes a reaction that exposes a single strand of DNA to act as a template for transcription. b) (5) Which of the following would NOT be an effect of phosphorylation of the C-terminal domain (CTD) of RNA Pol II? X Makes Pol II have a more positive charge. Makes Pol II more processive. Decreases affinity of Pol II for the rest of the PIC.
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