MCB121 W12 L17

MCB121 W12 L17 - MCB121 Ubiquitin/Proteasome practice...

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MCB121 Ubiquitin/Proteasome practice problems 1. Describe two steps in the process of ubiquit yl ation and degradation of a targeted protein that require ATP hydrolysis. 2. Which of the following is not a location to which a ubiquitin protein can be linked through its C-terminal end. A cysteine residue in another protein. A lysine residue of another protein. The N-terminus of another ubiquitin protein. A lysine residue in another ubiquitin. A cysteine residue in another ubiquitin protein. 3. Two particular lysines (K21 and K22) in I κ B appear to be targets for ubiquit yl ation in the process of NF κ B activation. If you were to mutate these two lisines to arginines, what effect would you expect this to have on the activation of NF κ B in cells containing the mutant proteins?
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Solutions 1. Describe two steps in the process of ubiquit yl ation and degradation of a targeted protein that require ATP hydrolysis.
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This note was uploaded on 03/16/2012 for the course MCB MCB 121 taught by Professor Gasser,burgess during the Winter '11 term at UC Davis.

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MCB121 W12 L17 - MCB121 Ubiquitin/Proteasome practice...

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