Unformatted text preview: 3. What is angiogenesis and how is it involved in tumor growth? Angiogenesis refers to the sprouting of new capillaries from pre-existing blood vessels. This is induced by a specific signal (e.g., VEGF / VEGFR2 interaction). It is thought to play a vital role in the survival and growth of solid tumors. 4. What are the biological model systems that S. De, et al . use to test their hypothesis? In vitro : established human cancer cell lines (LNCaP prostate cancer; MBA breast cancer). These cell lines have been further modified in this study by transfecting them with both normal and mutant versions of genes coding for a5b3 integrin. In vivo : human sc xenografts (LNCaP and MBA cells injected sub c utaneously into SCID mice)...
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- Fall '10
- S. De, tumor cell VEGF, B. INTEGRINS