BIS 104 PQ 32 - 3-associated p66 Shc. d. Phosphorylation of...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
BIS 104 PQ 32 The conclusions that can be derived from all of the experimental data presented in Figures 1 – 6 in the S. De et al. article can be summed up in four simple statements: a. The activation state of α 3 β 5 integrin plays a critical role in tumor growth in vivo by influencing VEGF expression. b. Stimulation of VEGF expression depends on α 5 β 3 clustering, a function impaired by the β 3 S752P mutation. c. α 3 β 5 clustering promotes recruitment of p66 Shc and phosphorylation of
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 3-associated p66 Shc. d. Phosphorylation of p66 Shc is a necessary step for 5 3-mediated potentiation of VEGF expression and tumor vascularization in vivo. Taken all together, these findings provide insight into the role of 5 3 integrin as a regulator of angiogenesis and tumor growth. 32. For each of the 4 statements given above, describe the key experimental result(s) that support that particular statement. a. b. c. d....
View Full Document

This note was uploaded on 03/16/2012 for the course BIOLOGY BIS104 taught by Professor Bejjamin during the Fall '10 term at UC Davis.

Ask a homework question - tutors are online