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1-12 - Steps of Neural Development o Neurulation GA 3-5...

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Steps of Neural Development o Neurulation GA 3-5 weeks o Patterning GA 3-5 weeks o Proliferation GA 5 weeks-6 months o Migration GA 5 weeks-6 months o Differentiation GA 25 weeks-6 months o Elimination PN 6 months-8 years Make about 2X the neurons you need, then during differentiation and elimination they are refined If you have to choose to have a developmental disorder, would you want an early or late one? Late, because they wouldn’t be as bad Neurulation o Begins around GA day 17, 18 o Development of mesoderm o Mesodermal induction: you need a signal from the mesoderm that induces the ectoderm to differentiate either into skin or neural tissue o Neural groove—neural fold—neural tube o Appearance of neural crest cells o Rostral (toward head) closure @ day 25 o Caudal closure @ day 27 now you’ve got a closed tube, and once you have a closed tube (entire nervous system with one layer of cells around it and a hollow tube) o
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1-12 - Steps of Neural Development o Neurulation GA 3-5...

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