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Unformatted text preview: Lambert-Eaton myastenic syndrome o Problem controlling muscles, autoimmune Ca2+ destroyed Latroxin =massive release w/o calcium, from black widow spider, bypasses need for calcium Botulism o Bacterium Clostridium botulinum o Toxin interferes with muscle contraction/can cause paralysis o Small doses used in BOTOX Naxos disease o 2 causative genes coding for proteins plakoglobin and desmoplakin o woolly hair, progressive heart disease Yersinia (food/water borne) o cell adhesion with cadherins, targets cell surface proteins Listeria (raw meats) o 25% lethal can cause bacterial meningitis o hijack normal cell adhesion of gut Ehlers-Danlos Syndrome o Collagen Defect o Can stretch skin and bend joints abnormally Marfans Syndrome o Defect in Elastin o Able to bend joints abnormally....
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- Spring '12