Unformatted text preview: BIS101-001: Genes and Gene Expression Linkage, Recombination and Constructing Genetic Maps Lecture #4b March 19, 2012 BIS101001, Spring 2012--Genes and Gene Expression, R.L. Rodriguez 2012 1 This Lecture Two genes close together on the same chromosome do not assort independently. New combinations of parental alleles can results from either inter- or intrachromosomal recombination. Pairs of homologous chromosomes can exchange segments of non-sister chromatids by crossing over. Gene loci on chromosomes can be mapped by measuring the frequency of intrachromosomal recombination in meiosis Genetic map distances based on RF are roughly additive. The occurrence of a crossover can be influenced by a second cross nearby (interference).
BIS101001, Spring 2012--Genes and Gene Expression, R.L. Rodriguez 2012 2 March 19, 2012 Key Concepts
Genetic linkage: Unlike Mendel's experiments, genes can be linked to each other or reside on the same chromosome. If two genes are close together on the same chromosome pair, they do not assort independently. Genetic distan...
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- Genetic linkage, Chromosomal crossover, R.L. Rodriguez ©2012