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9-9-10 - Hemophilia X(h = X w allele that does NOT code for...

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9-9-10 Hemophilia X(h) = X w/ allele that does NOT code for clotting X = X w/ “clotting” allele Who’s is more likely to have X-inked recessive diseases? Males If a “bad” allele on X, nothing on Y to compensate B. Chromosomal Abnormalities - Ex. Down’s syndrome, fragile X (X0, XXX, XXY, XYY) - Environment can help them grow up semi-independent - Down’s syndrome – Three 21 st autosomes o Meiosis- chromosomes don’t separate properly o During crossing over, 3 goes to 1 sister cell, and 1 goes to the other o End count – 2 – 1 – 1 – 0 in each cell. o Fragile X: CGG repeats C. Polygenic Traits: Due to multiple genes - Most psychological and some physical traits (skin color) IV. Additional reason why some deadly genes don’t fade away - Heterozygotes may be protected against other disease. o Ex. Sickle cell anemia Autosomal recessive S= normal blood s= sickle cells SS = normal blood ss= sickle cells - anemia and pain Ss = mild anemia because S not fully dominant over s Advantages of Ss? Protects against malaria
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