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14 - Reversal of maternal programming of stress responses, Weaver, I.C.G.

14 - Reversal of maternal programming of stress responses, Weaver, I.C.G.

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14. reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life hypothalamic-pituitary-adrenal (HPA) response to stress is an inducible defense in mammals that is activated in response to threat o there are maternal effects on the magnitude of such defensive responses in the offspring Magnitude of HPA hypothalamic-pituitary-adrenal response to stress –a function of neural stimulation of hypothalamic corticotrophin-releasing factor (crf) release (activates pituitary-derenal system) + modulartory influences (ie. glucocorticoid- negative feedback which inhibit CRF synthesis and release). the difference in hippocampal glucocortoid receptor (GR) expression serves as a mechanism for the effect of early experience on the development of individual differences in HPA responses to stress variations in maternal behaviour can directly program rudimentary defensive responses to stress and serve as a mechanism for the nongenomic transmission of individual differences in stress reactivity across generations epigenetic mechanisms are involved in the long-term maternal programming of
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