14 - Reversal of maternal programming of stress responses, Weaver, I.C.G.

14 - Reversal of maternal programming of stress responses, Weaver, I.C.G.

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
14. reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life hypothalamic-pituitary-adrenal (HPA) response to stress is an inducible defense in mammals that is activated in response to threat o there are maternal effects on the magnitude of such defensive responses in the offspring Magnitude of HPA hypothalamic-pituitary-adrenal response to stress –a function of neural stimulation of hypothalamic corticotrophin-releasing factor (crf) release (activates pituitary-derenal system) + modulartory influences (ie. glucocorticoid- negative feedback which inhibit CRF synthesis and release). the difference in hippocampal glucocortoid receptor (GR) expression serves as a mechanism for the effect of early experience on the development of individual differences in HPA responses to stress variations in maternal behaviour can directly program rudimentary defensive responses to stress and serve as a mechanism for the nongenomic transmission of individual differences in stress reactivity across generations epigenetic mechanisms are involved in the long-term maternal programming of
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/18/2012 for the course BIO 3UU3 taught by Professor Dr.rollo during the Spring '12 term at McMaster University.

Page1 / 2

14 - Reversal of maternal programming of stress responses, Weaver, I.C.G.

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online