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19 - Towards a molecular understanding of adaptive thermogenesis - Lowell, B.B.

19 - Towards a molecular understanding of adaptive thermogenesis - Lowell, B.B.

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Article #19 – Towards a Molecular Understanding of Adaptive Thermogenesis obesity is the result of energy imbalance, when energy intake exceeds expenditure calories are the measure of heat given off during exothermic reactions of metabolism thermogenesis – energy expenditure when heat is produced Adaptive Thermogenesis (facultative thermogenesis): regulated production of heat Influenced by environmental temp and diet Protects organism from cold exposure, regulates energy balance after changes in diet Many reactions in energy metabolism exothermic Total Body Energy Expenditure: Conversion of oxygen and food to carbon dioxide, heat, water and work Measured directly as heat produced or indirectly as oxygen consumed Obesity: Cumulative in nature, so can develop even when energy imbalance very small Temperature: 2-4 fold increase in O 2 consumption after exposure to cold, partly due to shivering, with adaptation get adaptive thermogenesis in brown adipose tissue Humans have larger thermoneutral zone then rodents – small changes in MR with large changes in temp (partially due to behavioural responses ie amt clothing) Diet: regulator of adaptive thermogenesis
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