{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

22 - Orexins, a novel family of hypothalamic neuropeptides, Pu, S.

22 - Orexins, a novel family of hypothalamic neuropeptides, Pu, S.

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Article #19 – Orexins, a Novel Family of Hypothalamic Neuropeptides, modulate Pituitary Luteinizing Hormone Secretion in an Ovarian Steroid-Dependent Manner NPY, galanin and opiods link the neural processes that regulate reproduction and energy intake produced in the medial basal hypothalamus stimulate appetite and affect secretion of pituitary gonadotropin, leutenizing hormone (LH), by modulating release o fhypothalamic leteinizing hormone releasing hormone (LHRH) orexin producing neurons are localized in the lateral hypothalamus and perifornical area innervate the posterior hypothalamus orexins stimulate feeding in a dose related fashion Orexin A more effective than orexin B at stimulating feeding orexin upregulation is in response to energy depletion orexins may play a key role in hypo. regulation of reproduction
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: • Alteration in nutritional status have profound effects on reproduction • Central mechanisms coordinating energy homeostasis and reproduction reside in hypothalamus • NPY, galanin and opioids stimulate appetite and affect secretion of pituitary gonadotropin, luteinizing hormone (LH) by modulating release of hypothalamic LHRH • Imbalanced energy intake = depressed pituitary-gonadal function • In steroid primed rates, Orexin A and B stimulated LH (but A more so than B) • In unprimed rats, both orexins inhibited LH secretion • orexins exert a modulatory influence on pituatory LH secrection • Orexins may act as an excitatory signal in hypothalamic control of LH secretion in intact female rats • NPY may be one of mediators of effects of orexins • Mating stimulates and fasting inhibits gonadotropin secretion...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern