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Unformatted text preview: • Alteration in nutritional status have profound effects on reproduction • Central mechanisms coordinating energy homeostasis and reproduction reside in hypothalamus • NPY, galanin and opioids stimulate appetite and affect secretion of pituitary gonadotropin, luteinizing hormone (LH) by modulating release of hypothalamic LHRH • Imbalanced energy intake = depressed pituitary-gonadal function • In steroid primed rates, Orexin A and B stimulated LH (but A more so than B) • In unprimed rats, both orexins inhibited LH secretion • orexins exert a modulatory influence on pituatory LH secrection • Orexins may act as an excitatory signal in hypothalamic control of LH secretion in intact female rats • NPY may be one of mediators of effects of orexins • Mating stimulates and fasting inhibits gonadotropin secretion...
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This note was uploaded on 03/18/2012 for the course BIO 3UU3 taught by Professor Dr.rollo during the Spring '12 term at McMaster University.
- Spring '12