24 - Oxidants, oxidative stress and the biology of ageing, Finkel, T.

24 - Oxidants, oxidative stress and the biology of ageing, Finkel, T.

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Article #21 – Oxidants, Oxidative Stress and the Biology of Ageing Rate of Living Hypothesis: metabolic rate of a species ultimately determines its life expectancy Free Radical Theory of Ageing: Denham Harman, mid-1950’s ROS generated in cells resulting in pattern of cumulative damage Superoxide dimutase (SOD) 2 – enzymes whose sole function was to remove superoxide anions – proved this hypothesis Two Theories Combines: Mitochondria consume bulk of intracellular oxygen, therefore, higher MR = greater production of ROS and shorter lifespan Exceptions: Birds and primates tend to live longer, mitochondria from these species tend to produce fewer ROS ROS production rather than MR is most correlated with longevity ROS (Reactive Oxygen Species): specific signaling molecules Generation essential to maintain homeostasis ie. Combat infection Rise in intracellular oxidant levels causes damage to various cell components and triggers activation of specific signaling pathways can affect cellular processes linked to ageing and development of age related diseases Can be generated exogenously or produced intracellularly
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