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26 - Endogenous Oxidative Stress, Barja

26 - Endogenous Oxidative Stress, Barja - Article 26...

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Article 26 – Endogenous Oxidative Stress: Relationship to Aging, Longevity and Caloric Restriction ageing: limits maximal functional capacities, decreases homeostasis, increases the probability of suffering degenerative diseases and finally death mainly caused by free radicals produced by mitochondria ageing is progressive and endogenous free radicals: superoxide, H 2 O 2 , HO 2 . , or HO . ROS scavenging is not 100% efficient leading to oxidative damage Oxygen radicals produced by the mitochondria are involved in the determination of the rate of aging Oxidative damage to tissues increases with aging oxygen radicals can attack DNA at sugar phosphate backbones, and bases producing single and double stranded breaks mice have a higher accumulation of point breaks in mtDNA compared to humans because they live shorter, which means they produce more ROS Mitochondrial oxygen radical generation is negatively correlated with animal longevity
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