Eleven - Enzyme Regulation

Eleven - Enzyme Regulation - Enzyme Regulation Critical for...

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2/29/12 MCB 2000 Lecture 14 Enzyme Regulation Critical for Adaptation
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2/29/12 MCB 2000 Lecture 14 Mechanisms of enzyme regulation • Catalytic activity of an enzyme is regulated so that the amount of a product is sufficient to meet the needs of the cell • Enzymes can exhibit a range of activity dependent on the physiological state of the cell: Example of adaptation
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2/29/12 MCB 2000 Lecture 14 If enzymes are not always maximally active, how is their activity regulated?
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2/29/12 MCB 2000 Lecture 14 Mechanisms of enzyme regulation Substrate concentration —has limitations Amount of enzyme increase de novo synthesis; gene activation— can be slow process protein degradation Allosteric control —rapid process activators/inhibitors; feedback inhibition Reversible covalent modification: phosphorylation and other types Zymogen activation —generally irreversible YOU SHOULD BE FAMILIAR WITH ADVANTAGES AND DISADVANTAGES OF EACH
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2/29/12 MCB 2000 Lecture 14 Allosteric Enzymes--
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Eleven - Enzyme Regulation - Enzyme Regulation Critical for...

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