Exam 2 Study Guide

Exam 2 Study Guide - D The relationship between protein...

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D. The relationship between protein structure and function: Hemoglobin (Hb) and Myoglobin (Mb) as examples Similarities and differences between Hemoglobin and Myoglobin Myoglobin stores oxygen in muscle Hemoglobin transports oxygen, CO 2 , H + Single polypeptide chain; monomer Tetramer: two α & two β subunits Only tertiary Important role in pH balance Heme structure is very hydrophobic Show allosteric behavior How are the oxygen saturation curves different? What does this tell you about the structure? Myoglobin o Myoglobin is hyperbolic Hemoglobin o Hemoglobin is sigmoidal(S-shaped) What is the physiological significance of cooperative binding? sigmoid shape of oxygen saturation indicates cooperativity between subunits in binding oxygen o bind of oxygen to one subunit disrupts some noncovalent interactions while forming new ones o Alteration in conformation makes it easier for oxygen to bind other subunits o (R) conformation = oxygenated o (T) conformation = deoxygenated All protein that show allosteric behavior require 3 characteristics Quaternary - need to communicate to other polypeptides
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This note was uploaded on 03/19/2012 for the course BIO 2000 taught by Professor Ewr during the Spring '12 term at Alabama.

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Exam 2 Study Guide - D The relationship between protein...

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