Fifteen - Introduction to Metabolism

Fifteen - Introduction to Metabolism - Introduction to...

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3/19/12 Introduction to Metabolism ‘The Big Picture’ fed fasted MCB 2000 Lecture 18
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3/19/12 Metabolism Involves: • A balancing act: homeostasis • Maintaining a constant level of blood glucose why is this necessary? how is this accomplished? • Redistribution of chemical energy between compounds • Integration of metabolic pathways • Repeating patterns MCB 2000 Lecture 18
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3/19/12 Metabolic Homeostasis MCB 2000 Lecture 18
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3/19/12 Signals that Regulate Metabolic Homeostasis ARC region of hypothalamus controls feeding: 2 types of neurons: (1) feeding promoting neuropeptides (orexigenic) (2) feeding inhibiting neuropeptides (anorexigenic) MCB 2000 Lecture 18
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3/19/12 (BMR) Maintaining the Balance Between Energy Expenditure and Energy Intake MCB 2000 Lecture 18
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3/19/12 • Importance of maintaining blood glucose Daily need for glucose 160 grams Brain needs ~120 grams Body fluids 20 grams Glycogen stores 190 grams ~4.5 mM MCB 2000 Lecture 18
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3/19/12 How is blood glucose regulated? Glucose itself Importance of 2 hormones insulin Glucagon Both insulin and glucagon alter the activity of enzymes by changes in phosphorylation/dephosphorylation (respective signal transduction cascades) MCB 2000 Lecture 18
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Fifteen - Introduction to Metabolism - Introduction to...

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