Five - Protein Structure

Five - Protein Structure - Protein Structure & Function...

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How do we go from linear sequence to folded structure to folded structure? Protein folding a) levels of protein structure i. primary, secondary, tertiary, quaternary ii. characteristics of each b) significance of Anfinsen's ribonuclease experiment c) factors that determine how a protein will fold? consequences of misfolding Levels of Protein Structure primary secondary tertiary quaternary Secondary Structure: Involves H-bonds between NH and CO along polypeptide backbone examples a) α -helix b) β -sheet c) β -turns Both α -helix and β -sheet are repetitive structures a) stabilized by H-bonding along the polypeptide backbone. b) R-groups do not participate in 2 ° structure Protein Secondary Structure: the alpha helix H-bonding stabilizes the α -helix each peptide bond is connected by hydrogen bonds to a peptide bond 4 amino away.
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This note was uploaded on 03/19/2012 for the course BIO 2000 taught by Professor Ewr during the Spring '12 term at Alabama.

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Five - Protein Structure - Protein Structure & Function...

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