Five - Protein Stucture & Function

Five - Protein Stucture & Function - The Folding...

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1/30 and 2/1/12 MCB 2000 Lecture 6 The Folding Problem
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How do we go from linear sequence to folded structure??? 1/30 and 2/1/12 MCB 2000 Lecture 6
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1/30 and 2/1/12 MCB 2000 Lecture 6 Lecture Outline: Protein Structure & Function • Protein folding – Levels of protein structure • Primary, secondary, tertiary, quaternary • Characteristics of each – Significance of Anfinsen’s ribonuclease experiment – Factors that determine how a protein will fold? • Consequences of misfolding How do we go from linear sequence to folded structure???
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1/30 and 2/1/12 MCB 2000 Lecture 6 Levels of Protein Structure • Primary • Secondary • Tertiary • Quaternary
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MCB 2000 Lecture 6 Secondary Structure: Involves H-bonds between NH and CO along polypeptide backbone • Examples -helix -sheet -turns Both -helix and -sheet are repetitive structures • Stabilized by H-bonding along the polypeptide backbone. • R-groups
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This note was uploaded on 03/19/2012 for the course BIO 2000 taught by Professor Ewr during the Spring '12 term at Alabama.

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Five - Protein Stucture & Function - The Folding...

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