Fourteen - Signal Transduction II (Insulin)

Fourteen - Signal Transduction II (Insulin) - Interactions:...

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3/9/12 MCB 2000 Lecture 17 Signal Transduction Part 2 How do cells sense and process information?
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3/9/12 MCB 2000 Lecture 17 Receptor Tyrosine Kinases The Insulin Receptor
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3/9/12 MCB 2000 Lecture 17 The insulin receptor is a tyrosine kinase that becomes activated on insulin binding. The insulin receptor phosphorylates itself and other proteins, particularly insulin- receptor substrate (IRS). Kinase Domain
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3/9/12 MCB 2000 Lecture 17 Insulin Signalling: No G-protein involved Multiple Protein-Protein
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Unformatted text preview: Interactions: Creates a Scaffold 3/9/12 MCB 2000 Lecture 17 Insulin Signalling: Another Role for PI IRS relays the insulin signal intracellularly. Phosphorylated IRS-1 activates PI-3-kinase. Phosphorylated PI creates a docking site . 3/9/12 MCB 2000 Lecture 17 How does insulin result in an increase in the number of glucose transporters on the plasma membrane? 3/9/12 MCB 2000 Lecture 17 Termination of Insulin Signalling Requires activity of protein phosphatases and lipid phosphatases...
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This note was uploaded on 03/19/2012 for the course BIO 2000 taught by Professor Ewr during the Spring '12 term at Alabama.

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Fourteen - Signal Transduction II (Insulin) - Interactions:...

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