Seven - Myoglobin & Hemoglobin

Seven - Myoglobin & Hemoglobin - Hemoglobin &...

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2/6/12 MCB 2000 Lectures 7 & 8 Hemoglobin & Myoglobin • Illustrates important concepts – Relationship between protein structure & function – Importance of noncovalent interactions • Reversible binding of a ligand to a protein – Buffering capacity
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2/6/12 MCB 2000 Lectures 7 & 8 Hemoglobin & Myoglobin • Proteins are evolutionarily related; share sequence homology • First proteins crystallized to determine structure by X-ray crystallography • Both contain the heme prosthetic group (prosthetic groups are permanently associated with a protein and contribute to its function)
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2/6/12 Hemoglobin vs Myoglobin • Myoglobin stores oxygen in muscle • Single polypeptide chain; monomer Mb: 153 aa, 17,200 MW • Hemoglobin transports oxygen, carbon dioxide, H+ • Important role in pH balance • Tetramer: two alpha subunits of 141 residues, 2 beta subunits of 146 residues
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2/6/12 MCB 2000 Lectures 7 & 8 Why Heme for Oxygen Binding? • Oxygen is poorly soluble in water. – diffusion through tissue ineffective • Transition metals have a strong tendency to bind oxygen.
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Seven - Myoglobin & Hemoglobin - Hemoglobin &...

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