Ten - Allosteric Enzymes

Ten - Allosteric Enzymes - Allosteric Enzymes-DO NOT show...

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2/27/12 MCB 2000 Lecture 13 Allosteric Enzymes- - DO NOT show Michaelis-Menten kinetics Michaelis-Menten Hyperbolic Allosteric Sigmoidal
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2/27/12 MCB 2000 Lecture 13 What do we mean by allosteric ? Allosteric--derived from the Greek--meaning other shape Characterized by sigmoidal kinetics (as opposed to Michaelis-Menton kinetics) show cooperativity quaternary structure (note: hemoglobin shows allosteric behavior although it is not an enzyme) Conformational change usually involves binding small effector molecules that are not substrates- -these bind to an allosteric site on the enzyme that result in rapid changes in enzyme activity.
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MCB 2000 Lecture 13 Allosteric behavior: an important characteristic of regulatory enzymes • Respond to environmental signals— adaptive response • ***Small changes in allosteric modifiers can result in large changes in activity.*** • This type of regulation may explain why enzymes are much larger than would be expected based on catalysis alone. • Catalyze the committed (rate-limiting step) in
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This note was uploaded on 03/19/2012 for the course BIO 2000 taught by Professor Ewr during the Spring '12 term at Alabama.

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Ten - Allosteric Enzymes - Allosteric Enzymes-DO NOT show...

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