Thirteen - Signal Transduction

Thirteen - Signal Transduction - 3/5 and MCB 2000 Lecture...

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Unformatted text preview: 3/5 and 3/7/12 MCB 2000 Lecture 16 Signal Transduction How do cells sense and process information? Molecular Circuits 3/5 and 3/7/12 MCB 2000 Lecture 16 Signal Transduction: An Adaptive Response • Signals • Receptors – cellular location • Signal amplification – G proteins – Second messengers – Activation of kinases and phosphatases • Cellular response • Signal Termination 3/5 and 3/7/12 MCB 2000 Lecture 16 Two Outcomes of Signal Transduction Pathways • Change the activity of an enzyme or group of enzymes • Increase or decrease gene expression 3/5 and 3/7/12 MCB 2000 Lecture 16 What are the signals? • hormones and growth factors • neurotransmitters • smells • taste sensations • light • extracellular matrix 3/5 and 3/7/12 MCB 2000 Lecture 16 General Characteristics of Signal Transduction Pathways • Specificity: Receptors – Plasma membrane • Polypeptide hormones; other molecules which are not permeable to the membrane – Cytoplasmic • Steroid hormones 3/5 and 3/7/12 MCB 2000 Lecture 16 Very Important General Characteristics of Signal Transduction Pathways...
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Thirteen - Signal Transduction - 3/5 and MCB 2000 Lecture...

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