Three- Amino Acids

Three- Amino Acids - Lecture Outline: Amino acids...

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1/27/12 MCB 2000 Lecture 4 Lecture Outline: • Amino acids – Importance of ionizable groups-acid base properties – Chemical & structural features – Classification—important for types of noncovalent interactions that determine protein structure
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1/27/12 MCB 2000 Lecture 4 General Structure of an Amino Acid At pH 7.0 (deprotonated) (protonated)
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1/27/12 MCB 2000 Lecture 4 Amino acids are optically active •The -carbon is the chiral center of the molecule (except for glycine). Only the L- configuration is found in proteins D- and L- mirror images
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1/27/12 MCB 2000 Lecture 4 Classification: It’s all in the R groups! The R group confers unique characteristics to each amino acid: vary in charge, shape, ability to H-bond, hydrophobicity, chemical reactivity.
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1/27/12 MCB 2000 Lecture 4 Classification of amino acids based on the chemical nature of their R group The most common scheme is: Nonpolar (hydrophobic): aliphatic, aromatic Polar (hydrophilic) uncharged Polar, acidic (negative charge, COO-) Polar, basic (positive charge, NH 3 + )
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MCB 2000 Lecture 4 Polar charged, negative Polar charged, positive 1/27/12
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1/27/12 MCB 2000 Lecture 4 -OH group Polar Uncharged carboxamide -SH group ***
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1/27/12 MCB 2000 Lecture 4 Nonpolar, aliphatic Branched chain thioether Ring structure; NOT aromatic
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Three- Amino Acids - Lecture Outline: Amino acids...

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