Endocrine II

Endocrine II - Higher Level Control Systems Learning...

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1 Higher Level Control Systems Learning Outcomes – Be able to: List examples of nervous control of hormone secretion • Describe regulation and effects of Growth Hormone • Describe regulation and effects of Thyroid Hormone • Describe how Thyroid hormone is synthesized • Describe the long-term stress response Diagram disruption of feedback control in Addison’s Disease and goiter due to hypothyroidism • Describe endocrine disorders (covered in class) Three main inputs control hormone secretion:
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2 Higher Level Control Systems: Nervous Control of Hormone Secretion • Adrenal gland’s production of NE and production of NE and EPI is controlled by ANS Higher Level Control Systems • ANS can influence production of Insulin and Glucagon by pancreas
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3 Higher Level Control Systems • Feedback control of Prolactin and Growth Hormone involves both the hormones themselves and hormone- induced changes in plasma levels of substances (Dopamine) Growth Hormone Regulation • Stimuli for GH Release: Exercise – Exercise –S t r e s s – Fasting – Low plasma [glucose] – Sleep – Raised plasma [arginine] Growth and metabolic Growth and metabolic effects – “Growth” effects include protein synthesis and mitosis
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4 Growth Hormone Regulation • Metabolic effects: Note that here GH is acting as an effector hormone: – Lipolysis – Increased blood [glucose] • “Growth” effects are mediated by somatomedins (including IGF-I) GH is acting as a tropic tropic hormone for GROWTH effects: – Cells uptake AAs, and synthesize proteins – Cellular proliferation – Increased sulfur uptake and cartilage formation Æ skeletal growth GH is an effector hormone and a tropic hormone
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5 Growth Hormone Regulation • Cell growth and division Æ consume arginine Æ removes stimulus for GH removes stimulus for GH secretion • Daily circadian rhythm of GH secretion (more at night) can be altered by: –E x e r c i s e ( Æ decreased blood [glucose] and stimulation of GH secretion
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Endocrine II - Higher Level Control Systems Learning...

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