Chm 635-5 - Glycogen Synthesis and Degradation are...

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1 Glycogen Synthesis and Degradation are controlled by Reciprocal Regulation Degradation Synthesis Glycogen Degradation and Synthesis are reciprocally regulated ATP G-6-P Glucose AMP 1. Phosphorylase is regulated by allosteric interactions and phosphorylation . 2. Glycogen synthase is regulated by phosphorylation only. G-6-P
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2 Regulation of Glycogen Degradation 1. Phosphorylase is regulated by allosteric interactions and reversible phosphorylation . 2. Phosphorylase is responsive to hormones such as insulin, epinephrine and glucagon . Muscles Liver Liver and muscle phosphorylase are 90% identical, but they differ in how they are regulated allosterically. 97 KD 97 KD
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3 The control of muscle glycogen phosphorylase activity. Hormones 1. Under physiological conditions, phosphorylase b is inactive. 2. In contrast, phosphorylase a is fully active . 3. When exercise commences, the elevated level of AMP leads to the activation of phosphorylase b. 4. Exercise also activates phosphorylation. 5. Glucose 6-phosphatase in muscles is absent.
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4 The control of liver glycogen phosphorylase activity. Hormones 90% identical to muscle phosphorylase Insensitive to AMP concentration Blood Glucose Regulates Liver Glycogen Metabolism
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5 Hormones Regulate Glycogen Synthesis and Degradation Phosphorylase Kinase is activated by phosphorylation and calcium ions
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6 Epinephrine and Glucagon signal the need for Glycogen breakdown Phosphorylase Kinase is inhibited and glycogen synthase is activated by insulin
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7 Regulation of glycogen metabolism by glucose in the liver Glycogen Breakdown and Synthesis are Reciprocally Regulated http://wps.prenhall.com/wps/media/objects/2398/2456197/AACLRQN0.mov http://www.wiley.com/college/fob/quiz/quiz15/15-21.html
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8 Insulin Modulates the Action of Glycogen Synthase in Several Ways The Actions of Insulin on Metabolism
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9 Hormones Regulate Glycogen Synthesis and Degradation Glucagon and Epinephrine Stimulate Glycogen Breakdown and Inhibit Glycogen Synthesis Glucagon and epinephrine stimulate glycogen breakdown – the opposite effect of insulin
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This note was uploaded on 03/20/2012 for the course CHM 635 taught by Professor Dr.kavitashah during the Spring '11 term at Purdue University-West Lafayette.

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Chm 635-5 - Glycogen Synthesis and Degradation are...

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