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Chm 635-5 - Glycogen Synthesis and Degradation are...

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1 Glycogen Synthesis and Degradation are controlled by Reciprocal Regulation Degradation Synthesis Glycogen Degradation and Synthesis are reciprocally regulated ATP G-6-P Glucose AMP 1. Phosphorylase is regulated by allosteric interactions and phosphorylation . 2. Glycogen synthase is regulated by phosphorylation only. G-6-P
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2 Regulation of Glycogen Degradation 1. Phosphorylase is regulated by allosteric interactions and reversible phosphorylation . 2. Phosphorylase is responsive to hormones such as insulin, epinephrine and glucagon . Muscles Liver Liver and muscle phosphorylase are 90% identical, but they differ in how they are regulated allosterically. 97 KD 97 KD
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