Chm 635-10 - Cancer and Glycolysis Gatenby Gillies Nature...

Info icon This preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Cancer and Glycolysis Gatenby & Gillies Nature 2004, 891.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 A near universal property of primary and metastatic cancers is upregulation of glycolysis. The mediastinal nodes (purple arrow) and supraclavicular nodes (green arrows) show high uptake of 18fluorodeoxyglucose (FdG), showing that tumours in these nodes have high levels of FdG uptake. The bladder (yellow arrow) also has high activity, because of excretion of the radionuclide. Upregulation of glycolysis leads to microenvironmental acidosis requiring evolution of phenotypes requiring evolution to phenotypes resistant to acid induced cell toxicity. Gatenby & Gillies Nature 2004, 891.
Image of page 2