Chm 635-11 - 1 Final exam May 2 nd 1-3 pm BRWN 3102 Fatty...

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Unformatted text preview: 1 Final exam May 2 nd 1-3 pm BRWN 3102 Fatty Acid Metabolism Fatty Acid Metabolism 2 A 16-C fatty acid with numbering conventions is shown. Most naturally occurring fatty acids have an even number of carbon atoms. The pathway for catabolism of fatty acids is referred to as the - oxidation pathway, because oxidation occurs at the -carbon (C-3). C O O 1 2 3 4 fatty acid with a cis- 9 double bond 3 Fatty Acid Metabolism Fatty Acid Metabolism 1. Building blocks for phospholipids and glycolipids , which are major components of cells. 2. Covalent attachment of fatty acids for membrane targeting . 3. Hormones and intracellular messengers . 4. Fuel , stored as triacylglycerols. Fatty acids play several important roles: Phospholipids 4 Phospholipids (Contd) Phospholipids (Contd) 5 Membrane Targeting: Farnesylation of Ras Hormones 6 Triacylglycerols are highly concentrated energy stores Triacylglycerols are highly concentrated energy stores 1. Reduced: The carbon in fatty acids (mostly -CH 2-) is reduced (so its oxidation yields the most energy possible). 2. Anhydrous: Fatty acids are not hydrated (as mono- and polysaccharides are), so they can pack more closely in storage tissues. 38 kJ/g for triacylglycerols, 17 kJ/g for carbohydrates and proteins. Non-polar. 3. Six times more energy in anhydrous fats versus hydrated glycogen. 4. Glucose and glycogen storage provides energy for 24 h. Fat storage provides energy for several weeks. 5. Triacylglycerols are stored in the cytoplasm of adipose cells. 6. Dietary lipids are digested by pancreatic lipases. 7 How Are Fats Mobilized from Dietary Intake and Adipose Tissue? Scanning electron micrograph of an adipose cell (fat cell). Globules of triacylglycerols occupy most of the volume of such cells. Fed-State Fasting State Liver Adipose Regulating Hormone Breaks down Glucose Synthesizes Fatty Acids Absorbs Fatty Acids released by Liver Synthesizes Triacyglycerides Insulin Glucagon Breaks down Fatty Acids released by Adipose tissue Synthesizes Ketone Bodies Breaks down Triacylglycerides releases Fatty Acids 8 Triacylglycerols (triglycerides) are the most abundant dietary lipids. They are the form in which we store reduced C for energy....
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This note was uploaded on 03/20/2012 for the course CHM 635 taught by Professor Dr.kavitashah during the Spring '11 term at Purdue University-West Lafayette.

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Chm 635-11 - 1 Final exam May 2 nd 1-3 pm BRWN 3102 Fatty...

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