Chapter 5 & 6 Bone -1-bone and skull

Chapter 5 & 6 Bone -1-bone and skull - Skeletal...

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Skeletal System I
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Sunday February 5, 2012 11:30 – 12:30 Bones on Sunday – Room 300 1:00 – 2:00 Bones on Sunday – Room 300 Room 300 is on the third floor of the Medical School Check website for directions to Room 300
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Function of the Skeleton Support - structural support for entire body - attachment of muscles - precise movements Storage of minerals - maintains normal concentrations in body fluids - calcium - 98% is deposited in bone - phosphates Blood cell production - red & white blood cells & platelets in red bone marrow Protection - skull - rib cage Leverage - change magnitude & direction of forces generated by skeletal muscles
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Bone as a Tissue Dense connective tissue Matrix - collagen fibers for flexibility - surrounded by calcium salts for strength - calcium phosphate joins with calcium hydroxide to form hydroxyapatite crystals Cells - osteoprogenitor cells - osteoblasts - osteocytes - osteoclasts
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Matrix 1/3 weight - collagen fibers – tough and flexible 2/3 weight - hydroxyapatite crystals - strong, but inflexible (Calcium phosphate + calcium hydroxide form hydroxyapatite crystals) 2% of total bone tissue volume - osteocytes which are surrounded by matrix
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Cells found in bone - osteocytes - osteoblasts - osteoprogenitor cells - osteoclasts
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Osteocytes mature bone cells completely surrounded by hard bone matrix maintain & monitor both protein and mineral content of matrix found in lacunae interconnected by canaliculi layers of matrix = lamellae
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Osteoblasts immature bone - forming cells develop into osteocytes synthesize osteoid secrete organic components of matrix calcifies to form hard matrix produces new bone – osteogenesis
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Osteoprogenitor Cells mesenchymal cells – stem cell produce osteoblasts play a role in fracture repair
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Chapter 5 & 6 Bone -1-bone and skull - Skeletal...

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