physsignaling - Role for Cell Signaling Is how cells...

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Unformatted text preview: Role for Cell Signaling Is how cells communicate with each other How cells receive, process and respond to information from the environment Chemical communication among cells Paracrine Autocrine Neural synaptic signaling Endocrine Cell-cell contact In paracrine signaling, cells secrete regulatory molecules that diffuse to nearby target cells Paracrine Signaling In synaptic signaling 1 neuron sends neurotransmitter messages to another cell via synapses synaptic signaling endocrine signaling Nonpolar regulatory molecules pass through plasma membrane, bind to receptors in nucleus, and affect transcription Examples include steroid and thryroid hormones and nitric oxide Cell to Cell Polar regulatory molecules bind to cell surface receptors Activated receptors send 2nd messengers into cytoplasm to mediate actions of regulatory molecule Water soluble hormones use cell surface receptors because cannot pass through plasma membrane General Signaling Scheme Receptors Convert extracellular signals (from signaling molecules) into intracellular signals that alter the behavior of the cell Localized to the plasma membrane Receptors are proteins Two components: A) ligand binding domain that nonconvavalently but stereospecifically bind the first messenger (extracellular) B) an effector domain that responses to the...
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physsignaling - Role for Cell Signaling Is how cells...

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