Lecture 9 Muscle II

Lecture 9 Muscle II - LS2 Muscle: mechanics Prof. George V....

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LS2 Muscle: mechanics Prof. George V. Lauder Office Hours: Friday 2-3+ (after class) and by appointment. Today: We focus on the neuromuscular junction and whole muscle mechanics. ***focus on material that explains in more detail topics covered in lecture*** Assigned Reading for this week: Custom text, pp. 274-316 (green page #s)
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Lecture outline Mechanisms of muscle contraction Sliding filament mechanism – brief review The neuromuscular junction Excitation-contraction coupling: the release of Ca++ Whole muscle mechanics Twitch and tetanus Length-tension curve Force-velocity curve
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Striated muscle structure
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In relaxed skeletal muscle, tropomyosin blocks the cross-bridge binding site on actin. Contraction occurs when calcium ions bind to troponin; this complex then pulls tropomyosin away from the cross-bridge binding site. Striated muscle structure
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Motor nerve cells make contact with muscle cells at the neuromuscular junction.
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This note was uploaded on 03/29/2012 for the course LS 2 taught by Professor Andrewa.biewener,petert.ellison,anddaniele.lieberman during the Fall '10 term at Harvard.

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Lecture 9 Muscle II - LS2 Muscle: mechanics Prof. George V....

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