Lecture 16.Blood.and.Hb

Lecture 16.Blood.and.Hb - LS2: Blood and Hb (hemoglobin)...

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LS2: Blood and Hb (hemoglobin) Prof. George V. Lauder Office Hours: Friday 2-3+ (after class) and by appointment. Assigned Reading for this lecture: Custom text, pp. 468-477; 559-571; (green page #s)
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Lecture outline Introduction: composition, flow, blood types and multiple roles of blood Blood and Hemoglobin (Hb) - O 2 transport carrier molecule Factors that affect Hb binding affinity for O 2 Myoglobin (skeletal muscle): facilitated diffusion Comparative blood saturation: fish and their swimbladder Sickle cell anemia (very briefly)
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Approximately 8% of an adult's body weight is made up of blood Females have around 4-5 liters, while males have around 5-6 liters Mean temperature is ~37-38 C It has a pH of about 7.35-7.45 Whole blood is about 4.5-5.5 times as viscous as water Introduction to blood
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Functions of blood • Gas exchange • Metabolism (metabolites, ions, fuels) • Waste elimination (renal filtration) • Hormone transport • Body defense: immune system • Fluid and ion balance • Heat transfer (storage & dissipation): temperature regulation ‘Hematocrit’ measures RBC (erythrocyte) count Low hematocrit: anemia (low Hemoglobin & Fe) Introduction to blood Hematocrit is a rapid assessment of blood composition: it is the percent of the blood volume that is composed of RBCs (red blood cells). Plasma includes water, ions, proteins, nutrients, hormones, wastes, etc.
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Erythrocytes Structure Biconcave, no nucleus Lack mitochondria Incapable of aerobic resp. Can’t do cellular repair Components Hemoglobin Lipids, ATP, carbonic anhydrase Function Transport oxygen from lungs to tissues and carbon dioxide from tissues to lungs Introduction to blood The cytoplasm of a RBC consists mainly of a 33% solution of hemoglobin (Hb). Circulating erythrocytes live for about 120 days. As an RBC ages, its membrane grows increasingly fragile. Many RBCs die in the spleen, where they become trapped in narrow channels, broken up and destroyed.
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Erythropoiesis Introduction to blood EPO, produced by specialized cells in the kidney, has been used to enhance athletic performance as a blood doping agent to increase the number of RBCs. Possible problems?
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The heart is the pump that propels the blood through the systemic and pulmonary circuits.
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This note was uploaded on 03/29/2012 for the course LS 2 taught by Professor Andrewa.biewener,petert.ellison,anddaniele.lieberman during the Fall '10 term at Harvard.

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Lecture 16.Blood.and.Hb - LS2: Blood and Hb (hemoglobin)...

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