LS2 Lect5

LS2 Lect5 - Pregnancy and birth Prof. Peter Ellison OfFce...

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Unformatted text preview: Pregnancy and birth Prof. Peter Ellison OfFce hours M 2-3 or by apt Chapter 24 (pp. 855-901) What s it all about? CATABOLISM ANABOLISM METABOLISM STORAGE Glucose Oxygen Amino acids Urea Carbon dioxide CATABOLIC STATE ANABOLIC STATE Implantation Placental form & function Parturition & birth Implantation Placental form & function Parturition & birth running out of food diffusion not adequate uterine lining about to be shed RU486 blocks progesterone receptors endometrium PROSTAGLANDINS stimulate smooth muscle contractions myometrium Must get food! Must let Mom know I m here! H uman C horionic G onadotropin Phew! HCG from the trophoblast/ placenta LH (luteinizing hormone) from the mother s pituitary half-life ~ 40 hrs half-life ~ 30 mins Klein, Stein, & Susser 1989 Probability of pregnancy loss Implantation Placental form & function Parturition & birth 5.5 5.5 5.5 5.5 10 1 8 3 6 5 10 1 8 6 4 2 9 7 5 3 MOTHER FETUS CON CURRENT DIFUSION MOTHER FETUS COUNTER-CURRENT DIFUSION MOTHER END FETUS END Hemochorial placenta mmol/min/kg 0.5 Maximal placental glucose fux sheep human Problems:...
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LS2 Lect5 - Pregnancy and birth Prof. Peter Ellison OfFce...

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