LS2 Lecture 15

LS2 Lecture 15 - Interested in Doing Research? Come to the...

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Interested in Doing Research? Come to the Life Sciences Undergraduate Research Fair Thursday, October 14 from 2-5 PM in the North Corridor of the Northwest Building Meet faculty from more than 60 labs at Harvard who will show posters describing their research. Meet post-docs, graduate students and undergraduates who are working in these labs. Find out about summer internship programs. Find out about funding and fellowship opportunities to support undergraduates engaged in research.
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Lecture #15 - Respiration Reading : Saladin et al. - Chapter 14 (pages 450 – 492)
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1. 2 transport in linked steps of diffusion and convection (bulk flow) 2. Branching architecture of lung airways, alveoli, and pulmonary circulation facilitate diffusive exchange 3. Air versus water as respiratory media & partial pressure of gases [effect of altitude] 4. Mechanics of breathing: tidal ventilation 5. Health related issues 6. Regulation of Respiration Outline
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1. 2 transport in linked steps of diffusion and convection (bulk flow) 2. Branching architecture of lung airways, alveoli, and pulmonary circulation facilitate diffusive exchange 3. Air versus water as respiratory media & partial pressure of gases [effect of altitude] 4. Mechanics of breathing: tidal ventilation 5. Health related issues 6. Regulation of Respiration Outline
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2 ) Transport Diffusion over short distances; bulk flow (convection) over long distances Lung Tissues Cardiovascular System ventilation diffusion convection diffusion (How well are these transport processes matched?) O 2 O 2 CO 2 CO 2
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Diffusion (effective over short distances) (Fick) Diffusion Eq: Diffusion Rate = K A (C out - C in ) L Δ C L K diffusivity constant ( α 1/molecular weight) A surface area Δ C concentration difference L barrier thickness (diffusion path) “concentration gradient” Adolph Fick (1855)
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Diffusion (effective over short distances) (Fick) Diffusion Eq: Diffusion Rate = K A (C out - C in ) L Δ C L K diffusivity constant ( α 1/molecular weight) A surface area Δ C concentration difference L barrier thickness (diffusion path) “concentration gradient” Design for diffusion: maximize surface area (A) for exchange minimize diffusion path (L) maximize concentration difference; hence Δ C/ L gradient Adolph Fick (1855)
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branching distribution of airways supply extremely small alveoli, enabling extreme increase in SA and short diffusion path (L) to enhance diffusive gas exchange . ~ 8 million!!
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This note was uploaded on 03/29/2012 for the course LS 2 taught by Professor Andrewa.biewener,petert.ellison,anddaniele.lieberman during the Fall '10 term at Harvard.

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LS2 Lecture 15 - Interested in Doing Research? Come to the...

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