Oxidative Stress

Oxidative Stress - 1 Oxidative Stress Oxidative Stress And...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Oxidative Stress Oxidative Stress And And Reactive Molecules Reactive Molecules 2 Oxidative Stress Oxidative Stress Occurs when reactive oxygen/nitrogen molecule formation exceeds the bodys natural defense system and antioxidants Result Damage to proteins, lipids, DNA, sugars and tissues 3 Results of Oxidative Stress Results of Oxidative Stress Damage from oxidative stress has been implicated in many conditions Aging and Cataracts Diabetes Cardiovascular disease Cancer Neurodegenerative diseases Alzheimers, Parkinsons, amylotophic lateral sclerosis (ALS) Inflammation Arthritis Inflammatory bowel disease 4 Objectives Objectives Understand why and how reactive oxygen/nitrogen molecules form Explain why molecules and tissues are damaged by reactive molecules, including: Lipids, Protein, DNA Measures of oxidative damage of tissues Explain how the bodys natural defenses and antioxidants can prevent/block damage from reactive molecules Primary defense mechanisms Secondary defense mechanisms 5 Oxygen Oxygen Air is 21% oxygen Good for aerobic organisms Not good for anaerobes Reduction of oxygen depletes anaerobe of essential electrons Kills organism Retrolental fibroplasia 6 Effect of O Effect of O 2 2 on Infection on Infection Colon, rectal, inflammatory bowel surgery 250 patients 30% oxygen 250 patients 80% oxygen 1 week post surgery 30% oxygen 28 infections 80% oxygen 13 infections 7 Atoms Atoms Element Protons Neutrons Electrons Outer-Shell Hydrogen 1 0 1 1 Carbon 6 6 6 4 Nitrogen 7 7 7 5 Oxygen 8 8 8 6 8 Molecules Molecules Atoms try to conform to octet rule 8 electrons in the outer orbit Electrons are usually paired Same orbit; opposite directions Anions add electrons to reach 8 (-) Cations lose electrons to remain at 8 (+) H C N O 9 Molecular Oxygen Molecular Oxygen Two electrons are not paired Different orbits Same direction x o : o x 10 Reactive Oxygen Molecules Reactive Oxygen Molecules O 2 Superoxide anion radical H 2 O 2 Hydrogen peroxide OH Hydroxyl radical ROO Peroxyl radical NO Nitric oxide radical ONOO Peroxynitrite anion 1 O 2 Singlet oxygen 11 Formation of Singlet Oxygen Formation of Singlet Oxygen Molecular oxygen can receive a photon of energy This energy is absorbed by an unpaired electron Singlet oxygen forms An electron becomes excited 12 Singlet Oxygen Singlet Oxygen x o : o x : o : o Unpaired electrons now are or 13 Energy Released From Energy Released From Singlet Oxygen Singlet Oxygen Immediately, singlet oxygen releases the photon of energy and reverts back to molecular oxygen....
View Full Document

This note was uploaded on 03/26/2012 for the course NDFS 435 taught by Professor Toryparker during the Winter '11 term at BYU.

Page1 / 84

Oxidative Stress - 1 Oxidative Stress Oxidative Stress And...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online