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Test 4 - March 19

Test 4 - March 19 - I Hallucinogens and PCP a Takes very...

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March 19, 2012 I. Hallucinogens and PCP a. Takes very little doses hallucinations a.i. Hallucinogens = mixed group of substances b. Lysergive acid Diethylamide (LSD) and peyote b.i. LSD – synthesized by Dr. Albert Hoffman, Swiss chemist in 1938 b.ii. From a fungus (Ergot) that grows on cereal grain b.iii. Effect on the brain b.iii.1. May affect the release of glutamate in the cerebral cortex b.iii.2. Also serotonin and similar pathways as CNS stimulants c. PCP (Phencyclidine) c.i. Created as an anesthetic (1952) c.ii. Effects on brain c.ii.1. PCP is an NMDA receptor antagonist c.ii.2. Dosage c.ii.2.a. Low dose: intoxication, euphoria or affective dulling, verbosity, slowed reaction, involuntary movements and weakness c.ii.2.b. Medium dose: disorganized thinking, distortions of body image, feelings of unreality, hostility, belligerence and violence c.ii.2.c. High dose: amnesia, surgical analgesia, seizures, hypothermia d. Club Drugs d.i. Ecstasy: stimulant + hallucinogen d.ii. Gamma-hydroxybutyrate (GHB): anabolic steroid + CNS depressant d.iii.
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  • Spring '12
  • MelissaMitchell
  • NMDA Receptor Antagonist, f.ii. Harm-Reduction models, Lysergive acid Diethylamide, Dr. Albert Hoffman, f.i. Disease Models

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