psych106-4

psych106-4 - Lecture 4 (Jan 19th): SYNAPSES AND DRUGS...

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Lecture 4 (Jan 19th): SYNAPSES AND DRUGS Lecture Outline 1) Types of Ion Channels - VOLTAGE-gated - NEUROTRANSMITTER-gated - STIMULUS-gated 2) Neurotransmitter (NT) Types 3) A Day in the Life of a NT 4) Two Main Types of NT-gated RECEPTORS - Ionotropic - Metabotropic Caffeine and Alcohol (for you to learn from book, just the basics )
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CONTROL (OPEN/CLOSE) OF ION CHANNELS 1) Voltage (i.e., Membrane Potential) (last lecture) 2) Neurotransmitter (NT) (today’s lecture) 3) But for the SENSES , the input STARTS with a Stimulus (e.g., LIGHT, SOUND or TOUCH) General Overview of NT Actions: NT Binds to receptors on neuron’s dendrites -> Opens “Neurotransmitter-GATED” Ion Channels -> Change in membrane potential -> If depolarization, and gets to –55 mV -> Action Potential -> travels down axon -> Releases NT at axon terminals into synapse -> and repeat
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Also, Purines and Gases NEUROTRANSMITTER (NT) TYPES A Day in the Life of a Neurotransmitter (NT)
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The neurotransmitter needs to GO AWAY! 1b
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6) The NT needs to go away! a) NT is re-absorbed by the presynaptic terminals, i.e., recycled e.g., Monoamines b) NT is altered (in the synapse) to an inactive state. i) broken down by enzymes e.g., Acetylcholinesterase (AChe): ACh -> acetate + choline choline reabsorbed and added to acetate ii) converted to an inactive state by enzymes e.g., MAO (monoamine oxidase), converts Monoamines to inactive state - drugs that inhibit MAO are used for depression c) Release of more NT is inhibited by activation of
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psych106-4 - Lecture 4 (Jan 19th): SYNAPSES AND DRUGS...

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