Seitz Bubble Point Test XLII

Seitz Bubble Point Test XLII - BUBBLE POINT TEST...

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BUBBLE POINT TEST Introduction Membrane filters have been used successfully for many years to remove yeast, bacteria and particulate from fluid streams. The ultimate integrity test for a sterilizing grade membrane filter is the bacterial challenge. Unfortunately this is a destructive test; the filter cannot be used afterwards to filter a product. As a result, one of the most important aspects of the use of filters to remove bacteria is to have a non-destructive integrity test, which is correlated to the production of effluent in a bacterial challenge test. It is this correlation, rather than the non- destructive integrity test alone, that provides assurance that the filter will perform as intended. During production of sterile product, the filter should be subjected to such an integrity test before and after filtration. This is done to ensure that the filter meets specification, is properly installed and intact during filtration, and to confirm the rating of the filter. There are 3 major tests used to determine the integrity of a membrane filter: the Bubble Point Test, the Forward Flow Test, and the Pressure Hold Test. All three tests are based on the same physics, the flow of a gas through a liquid-wetted membrane under applied gas pressures. They differ in which part of the flow/pressure spectrum they examine. In this paper, we will focus on the Bubble Point Test. Background
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This note was uploaded on 03/24/2012 for the course ENGINEERIN 100 taught by Professor Petroleum during the Spring '12 term at Manor.

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Seitz Bubble Point Test XLII - BUBBLE POINT TEST...

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