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LECTURE 2 PART 6 - 6 Substrates bind —=*reaction at he...

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Unformatted text preview: 6* Substrates bind —=- *reaction at he nsition state 3} Induced fit model for substmte binding a} Substrate afiectsthe shape of enzyme -:2- this shape change affects the shape change In} Decreaseentmpywifl'lin substatesto encourage the reaction :1 Enzyme has highest affinity for substrate when enzyme is in the induced fit form i] Brings reactantsto tmnsilion state d} 2 things to lower free energy ofactiyatjon [-LELG‘“) i} Strains bonds in 5Lbstrate molecule ii} Aligning substrate moleculfi in correct orientation to decrease entmpy ...
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