2012_Unit_1_Structure

2012_Unit_1_Structure - Midterm 3 = March 17 Finals cover...

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BIO 1140 Unit 1 – DNA, RNA b Reading s s Other sections referred to in the Figures b Objectives s Structure of DNA and RNA. “the static and the dynamic” asic chemistry BIO 1140 – SLIDE #1 c basic chemistry c basic structural forms c DNA and RNA modifications s Structure of DNA/protein in the cell. “why structure matters” c bacterial nucleoids c DNA-histone complexes c Midterm 3 = March 17 Finals cover EVERYTHING - in bio, lots of variation - arises by Darwinian evolution - inside cell- DNA is rarely naked - because of chemistry
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BIO1140 CELL BIOLOGY Examples of netiquette rules concerning peer respect (from Centre for University Teaching) • Be sure your device sound is set to “off” at the beginning of class BIO 1140 – SLIDE #2 • Stay on task. Activities such as Web surfing or gaming may distract classmates. • Listen to your classmates if they complain to you that your use is distracting
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b Key Questions that we will try to answer as we go along s What is the structure of DNA and how do we know? s Is DNA always the genetic material? s Is the DNA structure always the same? BIO1140 Unit 1 – DNA, RNA BIO 1140 – SLIDE #3 s Is the DNA structure in the cell relevant? s Without chromatin, would it be necessary to invent it? s Is the genome what we think it is? - experiment and results - not, but the consequences are more interesting than plus or minus of it - yes
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b s There are 4 nitrogenous bases (4 types, A, C,G, T) c (adenine, cytosine, guanine, thymine) s A base is a purine or pyrimidine c (adenine, cytosine, guanine, thymine) s A base + a pentose sugar = nucleoside. BIO1140 Unit 1 – DNA, RNA (Review Slide 1) BIO 1140 – SLIDE #4 c if the sugar is a deoxyribose,it is a deoxyribonucleoside (deoxyadenosine, deoxycytidine, deoxyguanosine, deoxythymidine) s A nucleoside + phosphate = deoxynucleotide c ( deoxyadenosine 5'-monophosphate, deoxycytidine 5'-diphosphate, etc.) s There are 5'-monophosphates, 5'-diphosphates, 5'- triphosphates c (deoxyadenosine 5'-monophosphate (dAMP), deoxadenosine 5'-diphosphate dADP), deoxadenosine 5'-triphosphate dATP). differences between DNA and RNA are in part due to the extra hydroxyl
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Other useful information: b The bases are heterocyclic, aromatic rings b The numbering system BIO1140 Unit 1 – DNA, RNA (Review Slide 2) BIO 1140 – SLIDE #5 Fig. 13-4, p. 276 If this was RNA what would change? b Uracil replaces thymine (no –Me group) b Ribose replaces deoxyribose (2’ OH) and hydroxyl if it was RNA - involved in structural changes or regulation - post-transcriptional changes
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b The Basic or Archetypal Structural Forms for DNA and RNA. Type of Organism
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2012_Unit_1_Structure - Midterm 3 = March 17 Finals cover...

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