2012_Unit_2-1_Replication

2012_Unit_2-1_Replication - - transcription - copying of...

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BIO 1140 – SLIDE #1 Unit 2 – Information flow Reading Chapter 13.3,13.4 Chapter 14 Chapter 15 Objectives DNA Replication in eucaryotes What is a gene? Transcription in eucaryotes Translation in eucaryotes Regulation Unit 2 – What explains the variety of systems and their regulation? DNA RNA Protein The Central Dogma Replication Transcription Translation BIO 1140 – SLIDE #2 BIO1140 CELL BIOLOGY Examples of netiquette rules concerning peer respect (from Centre for University Teaching) • Be sure your device sound is set to “off” at the beginning of class • Stay on task. Activities such as Web surfing or gaming may distract classmates. • Listen to your classmates if they complain to you that your use is distracting BIO 1140 – SLIDE #3 Unit 2 – Information flow DNA Replication in Eucaryotes Key Points to Remember (you likely know them already) The DNA structure is antiparallel. DNA strands go from 5’ to 3’. Two strands of parental DNA molecule unwind aided by helicases. Helicases unwind DNA to expose template strands for DNA synthesis. Each is a template for the synthesis of a complementary copy. Synthesis follows the base-pairing rules, A-T, G-C. DNA replication is semiconservative. One new DNA strand is synthesized continuously; the other, discontinuously. - transcription - copying of genes - replication - copy into two daughters - Watson and Crick - model suggested how you replicate and transcribe - RNA could be the final product - genes could give rise to them - synthesis always occurs from 5' to 3' - semiconservative - each strand of DNA is used as a template - reading the bases in 3' to 5' - need to unwind DNA for synthesis -helicases help - need enzymes to change topology but not the sequences are topoisomers - if there is a mistake made in synthesis - enzymes recognize it, repair and replace - one leading strand (continuous) the other lagging (discontinuous) --- semiconservative replication
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BIO 1140 – SLIDE #4 Unit 2 – Information flow DNA Replication in Eucaryotes Key Points to Remember (continued) Synthesis of DNA (or RNA) is ALWAYS 5’ to 3’ DNA polymerases are the primary enzymes of DNA replication. Multiple enzymes coordinate their activities in DNA replication. DNA replication begins at replication origins ( ori , ars ). RNA primers provide the starting point for DNA polymerase to begin synthesizing a new DNA chain Telomerases solve a specialized replication problem at the ends of linear DNA molecules BIO 1140 – SLIDE #5 Unit 2 – Information flow DNA Replication in Eucaryotes Key Points to CONSIDER Why do you need 3 types of DNA synthesis for a chromosome? (and multiple DNA polymerases in the cell?)
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This note was uploaded on 03/26/2012 for the course BIO 1140 taught by Professor Fenwick during the Winter '07 term at University of Ottawa.

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2012_Unit_2-1_Replication - - transcription - copying of...

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