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Ch11-120319 - CHEM 350 Introduction to Biological Chemistry...

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CHEM 350: Introduction to Biological Chemistry Brian Lee, Ph.D. [email protected] Of fi ce: Neckers 146G or 324 Phone: 453-7186 Hours: 9:30am to 10:30am or by appointment Website: https://online.siu.edu Textbook (required, U.S. edition only) Fundamentals of Biochemistry , 3 rd Ed., Voet, Voet & Pratt. Study Guide (recommended) Student Companion to Fundamentals of Biochemistry, 3 rd Ed. Help Desk Tuesday 6:30 to 7:30 pm in Neckers 218 Thursday 5:00 to 6:00 pm in Neckers 410
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Announcements Undergraduate Research Opportunities Research for credit (such as CHEM 396 or CHEM 496) Student worker ($8.00 per hour) ( http://www.siu.edu/~fao/jobs/ ) Undergraduate Assistantships ( http://undergraduateassistantship.siuc.edu/ ) McNair Scholars Program ( http://www.siu.edu/~mcnair ) REACH Awards Competition ( http://www.siu.edu/~reach/ )
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Assignments Read Chapter 12 Enzyme Kinetics Chapter 12 Problems Student Companion site for Voet, Voet & Pratt http://bcs.wiley.com/he-bcs/Books?action=index&bcsId=4274&itemId=0470129301 Third Midterm Exam, Wednesday March 28 th Chapters 10-13 Help Desk Tuesday 6:30 to 7:30 pm in Neckers 218 Thursday 5:00 to 6:00 pm in Neckers 410
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Catalytic Mechanisms •Acid-base catalysis •Covalent catalysis •Metal-ion catalysis •Electrostatic catalysis •Proximity and orientation •Transition state binding
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Lysozyme - antibacterial agent, lyses bacterial cell walls -attacks carbohydrates in peptidoglycan -cleaves glycosidic bond between Mur2Ac and GlcNAc -Mur2Ac: N-acetylmuramic acid (NAM) -GlcNAc: N-acetylglucosamine (NAG) found in tear drops and egg whites
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cleaves between D and E
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Transition state binding to the distorted half-chair conformation of NAM promotes cleavage of the glycosidic bond.
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Page 343 Isotope labeling to identify scissile bond
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Lysozyme uses: Glu35 COOH high pKa due to nonpolar environment Asp52 COO - stabilizes the carbocation-oxonium ion Mechanism of reaction without enzyme using general acid catalysis.
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