Ch12-120326 - CHEM 350 Introduction to Biological...

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Unformatted text preview: CHEM 350: Introduction to Biological Chemistry! "[email protected]! "Brian Lee, Ph.D. ! "Office: Neckers 146G or 324 "Phone: 453-7186! "Hours: 9:30am to 10:30am or by appointment! "Website: https:/ /! Textbook (required, U.S. edition only)! Fundamentals of Biochemistry, 3rd Ed., Voet, Voet & Pratt. ! Study Guide (recommended)! Student Companion to Fundamentals of Biochemistry, 3rd Ed. ! Help Desk! Tuesday 6:30 to 7:30 pm in Neckers 218! Thursday 5:00 to 6:00 pm in Neckers 410! Announcements! Undergraduate Research Opportunities! Research for credit (such as CHEM 396 or CHEM 496)! Student worker ($8.00 per hour) (! Undergraduate Assistantships (! McNair Scholars Program (! REACH Awards Competition ( (due Jan 30t ! ! Assignments! •! Third MidTerm Exam - Wednesday, March 28th! •! Chapters 10-13 ! •! Chapter 12 (skip section 4)! •! (Chapter 13: Sections 1, 2A and 2B)! ! ! Help Desk! Tuesday 6:30 to 7:30 pm in Neckers 218! Thursday 5:00 to 6:00 pm in Neckers 410! Regulation by! covalent modification! ! Phosphorylation! -kinase! -phosphatase! Covalent modification! can act as an on-off ! switch for an enzyme,! or shift the equilibrium! between T and R states.! Glycogen phosphorylase! glycogen( n ) + Pi " glycogen ( n # 1) + G1P Breakdown of glycogen! for energy metabolism.! ! ! Regulated by phosphorylation! of glycogen phosphorylase.! Ser 14 is phosphorylated.! Phosphorylase a dimer! -active site (pyridoxal phosphate)! -allosteric effector site! -glycogen binding site! -catalytic site! Phosphorylation stabilizes the R state through favorable! interactions with the Ser14 phosphate group by Arg569! Phosphorylation also changes which allosteric regulators! are recognized by phosphorylase:! phosphorylase b ( ATP, G6P, AMP) ! phosphorylase a (glucose)! ...
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