Chap 14 ppts - Functions of the kidney 1 Regulation of...

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1 Functions of the kidney 1. Regulation of inorganic ions (Na + , K + , Ca ++ , Cl - , Pi, Mg ++ ) 3. Excretion of nitrogenous wastes (urea, creatinine) 4. Excretion of foreign chemicals (drugs, pollutants, etc.) 5. Regulation of pH, and HCO 3 - 6. Synthesis of renin 7. Synthesis of erythropoietin; activation of vitamin D 3 8. Gluconeogenesis (liver much more important)
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2 Structure of urinary system fig 14-1
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3 Structure of kidney fig 14-4
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4 fig 14-2 Nephron: Bowman’s capsule (C) proximal tubule (C) loop of Henle (M) distal tubule (C) collecting duct (C, M) Blood supply afferent arteriole (C) glomerular capillaries (C) efferent arteriole (C) peritubular capillaries (C) vasa recta (M) venule (C) (C) = cortex (M) = medulla
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5 Blood flow: afferent arteriole glomerular capillaries efferent arteriole Filtration: from glomerular capillaries into Bowman’s capsule Cell types: juxtaglomerular apparatus (macula densa + juxtaglomerular cells) podocytes Structure of glomerulus (renal corpuscle) fig 14-3
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6 From plasma through capillary endothelial cell fenestrae & podocyte filtration slits into Bowman’s capsule. Fluid in Bowman’s capsule is protein-free filtrate of plasma Direction of filtration fig 14-3b
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7 Macula densa: specialized cells in wall of distal tubule Juxtaglomerular cells: contain renin, sympathetic nerves Juxtaglomerular apparatus fig 14-5
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8 Filtration: glomerular capillaries Bowman’s capsule Secretion: peritubular capillaries tubular fluid Reabsorption: tubular fluid peritubular capillaries Excretion = filtration + secretion – reabsorption Filtration, reabsorption, secretion, excretion fig 14-6
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9 + , K + , water) Kidney handling of various substances fig 14-7
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10 Glomerular filtration barrier fig 14-3c
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Forces of filtration fig 14-8 Compare with Starling forces in muscle capillaries
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This note was uploaded on 03/26/2012 for the course PHSL 310 taught by Professor Ferraro during the Fall '11 term at SIU Carbondale.

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Chap 14 ppts - Functions of the kidney 1 Regulation of...

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