Chap 16 ppts - Absorptive(fed state Definition the few...

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1 Absorptive (fed) state Definition: the few hours after a meal, an anabolic state Carbohydrate: glucose to liver, fat & muscle; main energy source in absorptive state forms glycogen (muscle, liver), triglyceride (adipose, liver) Protein: aminoacids to liver ( protein) Triglyceride: chylomicrons to adipose (storage) liver triglyceride VLDL to adipose (storage)
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2 Absorptive (fed) state fig 16-1
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3 Postabsorptive (fasted) state Definition: dependent on stored substrate, a catabolic state Carbohydrate: maintenance of blood glucose level critical (brain metabolism) glucose sources: liver glycogen, gluconeogenesis from protein Protein: muscle aminoacids to liver (gluconeogenesis glucose) Triglyceride: fatty acids ketone bodies (acetoacetate, β OH butyrate) in liver
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4 Postabsorptive (fasted) state fig 16-2
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5 Source: β cells of Islets of Langerhans in pancreas (endocrine pancreas) Structure: 51 aminoacid peptide, 2 chains joined by -S-S- bonds Release stimulated by: blood glucose concentration (most important) aminoacid concentration, GIP (glucose insulinotropic peptide) parasympathetic NS activity, sympathetic NS activity
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6 Insulin actions fig 16-4 Insulin is anabolic (synthesis of glycogen, protein, triglyceride)
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7 Insulin actions fig 16-6 Green arrows: stimulated by insulin Dotted red arrows: inhibited by insulin
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8 Regulation of blood glucose by insulin fig 16-7
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This note was uploaded on 03/26/2012 for the course PHSL 310 taught by Professor Ferraro during the Fall '11 term at SIU Carbondale.

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Chap 16 ppts - Absorptive(fed state Definition the few...

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