Unformatted text preview: receptor GPIb on the endothelium. Bleeding defects occur if no GPIa or GPIb. Platelet adherence leads to shape change, it spreads out. o Release; pre-formed and de-novo compounds that affect hemostasis and the metabolism of the vessel wall. Platelets releases PDGF, thrombospondin, platelet factor 4, fibrinogen, fibronectin and vWF from alpha granules. Platelets also release ATP, ADP, GDP, GTP, serotonin, and calcium from dense bodies. Can lead to the initiation of a clotting cascade. They also release arachidonate to make prostalandins that promote and prevent aggregation. o Aggregation; Platelets bind to each other using fibrinogen, which use GPIIb and IIIa integrins. The receptor may also bind vWF. The stimk...
View Full Document
- Spring '08
- Platelets, Thrombosis, Platelet, Platelets releases PDGF, bind glycoprotein receptors