Glutamate Receptors

Glutamate Receptors - Glutamate Receptors L-Glutamate is...

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Glutamate Receptors L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, ligand gated ion channels ( ionotropic receptors ) and G-protein coupled ( metabotropic ) receptors. Activation of these receptors is responsible for basal excitatory synaptic transmission and many forms of synaptic plasticity such as long-term potentiation (LTP) and long-term depression (LTD), mechanisms that are thought to underlie learning and memory. They are thus also potential targets for therapies for CNS disorders such as epilepsy and Alzheimer's diseases. A page detailing the structure and functions of various AMPA and NMDA receptor interacting proteins may also be found. Ionotropic Glutamate Receptors Structure of the ionotropic glutamate receptors Figure 1. General structure of an ionotropic glutamate receptor subunit. The large N- terminal domain is extracellular while the shorter C-terminal domain is intracellular. The ionotropic glutamate receptors are multimeric assemblies of four and are subdivided into three groups ( AMPA , NMDA and Kainate receptors) based on their pharmacology structural similarities. In addition, a further family of delta-receptor subunits have more recently been
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This note was uploaded on 03/30/2012 for the course BISC 230LXG taught by Professor Mcclure,greene during the Spring '08 term at USC.

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Glutamate Receptors - Glutamate Receptors L-Glutamate is...

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