09 Growth & Thyroid

09 Growth & Thyroid - PSL302Y: Lecture 09, by Prof....

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How do hormones control growth? Hormones : growth hormone, insulin-like growth factor 1 (IGF-1) 2-step bone growth (1) Chondrocytes (cartilage-producing cells of cartilage) form the epiphysial growth plate (2) Osteoblasts diffate to start ossi±cation (vs. osteoclasts responsible for bone remodeling) Growth, a complex process, depends on: - Diet: malnutrition will reduce growth - Genetics: affects rate of growth - Classical hormones work with growth factors - Growth hormone, thyroid hormone, insulin - Sex steroids - Cortisol - Insulin-like growth factor 1 (IGF-1) GH (directly) stimulates bone growth - GH targets bone matrix & liver - At bone matrix: recruits chondrocytes to develop growth plate - At liver: stimulates release of IGF-1 -> targets growth plate - Chondrocytes = recruitment proliferation matrix GH (directly & indirectly via IGF-1) stimulates bone remodeling - GH directly targets osteoblasts = recruitment of chondrocytes proliferation matrix - GH indirectly targets osteoclasts -> stimulates release of IGF-1 from liver - Two targets: osteoblasts & osteoclasts = recruitment matrix resorption GH, somatotropin - Synthesized in anterior pituitary; species speci±c
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This note was uploaded on 03/27/2012 for the course PSL PSL300 taught by Professor Mackayfrench during the Fall '11 term at University of Toronto.

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09 Growth & Thyroid - PSL302Y: Lecture 09, by Prof....

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